• hiPSC for assessing the potential health risks of environmental health
  
  With the advent of patient-specific induced pluripotent stem cells (iPSCs) that can be differentiated into cardiac cells and endothelial cells, investigation of e-cigarette vaping-related cardiovascular dysfunction with distinct human genetic background becomes feasible. A major focus of our research is to elucidate the epigenetic impact on the initiation and development of e-cigarette vaping-related cardiovascular dysfunction at the cellular level.
  
  
  
• hiPSC for studying influence of anticancer drugs on cardiovascular toxicity
  
  We focus on identifying mechanisms responsible for anticancer drugs-induced cardiovascular toxicity. Specifically, we are interested in assessing whether the integrated stress response (ISR) plays a role.