2023
- Yi D, Liu B, Ding H, Li S, Li R, Pan J, Ramirez K, Xia X, Kala M, Singh I, Ye Q, Lee WH, Frye RE, Wang T, Zhao Y, Knox KS, Glembotski CC, Fallon MB, Dai Z. E2F1 mediates SOX17 deficiency-induced pulmonary hypertension. Hypertension (Accepted).
- Nukala SB, Jousma J, Yan G, Han Z, Kwon Y, Cho Y, Liu C, Gagnon K, Pinho S, Rehman J, Shao NY, Ong SB*, Lee WH*, Ong SG*. Modulation of lncRNA links endothelial glycocalyx to vascular dysfunction of tyrosine kinase inhibitor. Cardiovasc Res, 119(10):1997-2013. PMID: 37267414. *Denotes Co-corresponding authors.
- Liu C, Le HHT, Denaro III P, Dai Z, Shao NY, Ong SG, Lee WH. E-cigarettes induce dysregulation of autophagy leading to endothelial dysfunction in pulmonary arterial hypertension. Stem Cells, PMID: 36640125.
- Jousma J, Han Z, Yan G, Nukala SB, Kwon Y, Le HHT, Li Y, Ong SB, Lee WH, Ong SG. Alteration of the N6-methyladenosine epitranscriptomic profile in synthetic phthalate-treated human induced pluripotent stem cell-derived endothelial cells. Epigenomics, PMID:36314267.
- Nukala SB, Jousma J, Cho Y, Lee WH, Ong SG. Long non-coding RNAs and microRNAs as crucial regulators in cardio-oncology. Cell & Bioscience, 12(1):24. PMID: 35246252.
- Le HHT, Liu C, Denaro III P, Jousma J, Shao N, Rahman I, Lee WH. Genome-wide differential expression profiling of lncRNAs and mRNAs in human induced pluripotent stem cell-derived endothelial cells exposed to e-cigarette extract. Stem Cell Research & Therapy, 12(1):593. PMID: 34863290.
- Joshi S, Lee WH, Chen P, Serpooshan V, Yang H. Editorial: 3D cell culture systems for cardiovascular tissue engineering: in vitro modeling and in vivo regenerative therapies. Frontiers in Cardiovascular Medicine, 8:675676. PMID: 34222371.
- Klionsky DJ, XX, Lee WH, XX, Zuckerbraun B. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1):1-382. PMID: 33634751.
- Jang HR, Cho HJ, Zhou Y, Shao NY, Lee K, Le HHT, Jeon J, Lee JE, Huh W, Ong SG, Lee WH, Kim YG. Modeling uremic vasculopathy with induced pluripotent stem cell-derived endothelial cells as a drug screening system. Frontiers in Cell and Developmental Biology, 8:618796. PMID: 33511129.
- Kwon Y, Nukala SB, Srivastava, S, Miyamoto H, Ismail NI, Jousma J, Rehman J, Ong, SB, Lee WH, and Ong SG. Detection of viral RNA fragments in human iPSC cardiomyocytes following treatment with extracellular vesicles from SARS-CoV-2 coding sequence overexpressing lung epithelial cells. Stem Cells Research & Therapy, 11:514. PMID: 33256833.
- Lee WH, Ong SG, Zhou Y, Tian L, Bae HR, Baker N, Whiplash A, Mojhammadi L, Guo H, Nadeau KC, Springer ML, Shick SF, Bhatngar A, Wu JC. Modeling cardiovascular risks of e-cigarettes with human induced pluripotent stem cell-derived endothelial cells. Journal of the American College of Cardiology, 73(21):2722-37. PMID: 31146818. (Accompanied Editorial).
- Guo H, Tian L, Zhang JZ, Kitani T, Paik DT, Lee WH, Wu JC. Single-cell RNA sequencing of human embryonic stem cell differentiation delineates adverse effects of nicotine on embryonic development. Stem Cell Reports, 12(4):772-786. PMID: 30827876.
- Ong SB*, Lee WH*, Shao NY, Ismail NI, Katwadi K, Lim MM, Kwek XY, Michel NA, Li J, Newson J, Tahmasebi S, Rehman J, Kodo K, Jang HR, Ong SG. Calpain inhibition restores autophagy and prevents mitochondrial fragmentation in a human iPSC model of diabetic endotheliopathy. Stem Cell Reports, 12(3):597-610. PMID: 30799273. *Denotes co-first authors.
- Ong SG, Lee WH, Zhou Y, Wu JC. Mining exosomal microRNAs from human-induced pluripotent stem cells-derived cardiomyocytes for cardiac regeneration. Methods in Molecular Biology, 1733:127-136. PMID: 29435928.
- Lee WH, Chen W, Shao N, Xiao D, Qin X, Baker N, Bae H, Shukla P, Wu H, Kodo K, Ong SG, Wu JC. Comparison of non-coding RNAs in exosomes and functional efficacy of human embryonic stem cell-versus induced pluripotent stem cell-derived cardiomyocytes. Stem Cells, 35(10):2138-2149. PMID: 28710827.
- Cho HJ, Lee WH, Hwang OH, Sonntag WE, Lee YW. Role of NADPH oxidase in radiation-induced pro-oxidative and pro-inflammatory pathways in mouse brain. International Journal of Radiation Biology, 93(11):1257-1266. PMID: 28880721.
- Hnatiuk A, Ong SG, Olea F, Locatelli P, Riegler J, Lee WH, Jen CH, Lorenzi AD, Gimenex C, Laguens R, Wu JC, Crottogini A. Allogeneic mesenchymal stromal cells overexpressing mutant human HIF1-α in an ovine model of acute myocardial infarction. Journal of the American Heart Association, 5(7):e003714. PMID: 27385426.
- Lee WH, Nguyen PK, Fleischmann D, Wu JC. DNA damage-associated biomarkers in studying individual sensitivity to low-dose radiation from cardiovascular imaging. European Heart Journal, 37(40):3075-80. PMID: 27272147.
- Hu S, Zhao M, Jahanbani F, Shao N, Lee WH, Chen H, Snyder MP, Wu JC. Effects of cellular origin on differentiation of human induced pluripotent stem cell-derived endothelial cells. Journal of Clinical Investigation Insight, 1(8):e85558. PMID:27398408.
- Riegler J, Ebert A, Qin X, Shen Q, Wang M, Ameen M, Kodo K, Ong SG, Lee WH, Lee G, Neofytou E, Gold JD, Connolly AJ, and Wu JC. Comparison of magnetic resonance imaging and serum biomarkers for detection of human pluripotent stem cell-derived teratomas. Stem Cell Reports, 6(2):176-87. PMID: 26777057.
- Ong SG, Huber BC, Lee WH, Kodo K, Ebert AD, Ma Y, Nguyen P, Diecke S, Chen WY, Wu JC. Microfluidic single cell analysis of transplanted human induced pluripotent stem cell-derived cardiomyocytes following myocardial infarction. Circulation, 132(8):762-71. PMID: 26304668.
- Ong SG, Lee WH, Kodo K, Wu JC. MicroRNA-mediated regulation of differentiation and transdifferentiation in stem cells. Advanced Drug Delivery Reviews, 88:3-15. PMID: 25887992.
- Nguyen P*, Lee WH*, Li YF, Hong WX, Hu S, Chan CK, Liang G, Nguyen I, Ong SG, Churko J, Wang J, Altman R, Fleishmann D, Wu JC. Assessment of the radiation effects of cardiac computed tomographic angiography using protein and genetic biomarkers. Journal of the American College of Cardiology Cardiovascular Imaging, 8(8):873-84. PMID: 26210695. (Accompanied Editorial) *Denotes co-first authors.
- Lee WH, Nguyen P, Hu S, Liang G, Ong S, Han L, Sanchez-Freire V, Lee AS, Vasanawala M, Segall G, Wu JC. Variable activation of DNA damage response pathways in patients undergoing SPECT myocardial perfusion imaging. Circulation Cardiovascular Imaging, 8(2):e002851. PMID: 25609688.
- Ong S*, Lee WH*, Theodorou L, Kodo K, Lim SY, Shukla DH, Briston T, Kiriakidis S, Ashcroft M, Davidson SM, Maxwell PH, Yellon DM, Hausenloy DJ. HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore. Cardiovascular Research, 104(1):24-36. PMID: 25063991. *Denotes co-first authors.
- Ong S*, Lee WH*, Huang M*, Dey D, Sanchez-Freire V, Kodo K, Gold JD, and Wu JC. Cross talk of combined gene and cell therapy in ischemic heart disease: role of exosomal microRNA transfer. Circulation, 130(11 Suppl 1):S60-69. PMID: 25200057. *Denotes co-first authors.
- Gu M, Nguyen PK, Xu D, Hu S, Plews J, Han L, Lee AS, Huber B, Lee WH, Gong Y, Almeida PE, Lyons J, Ikeno F, Connolly AJ, Robbins RC, Longaker MT, Wu JC. Microfluidic single cell analysis shows porcine induced pluripotent stem cell-derived endothelial cells improve myocardial function by paracrine activation. Circulation Research, 111(7): 882-893. PMID: 22821929.
- Lee YW, Cho HJ, Lee WH, Sonntag WE. Whole brain radiation-induced cognitive impairment: pathophysiological mechanisms and therapeutic targets. Biomolecules and Therapeutics, 20(4): 357-370. PMID: 24009822.
- Lee WH, Warrington JP, Sonntag WE, Lee YW. Irradiation alters MMP-2/TIMP-2 system and collagen type IV degradation in brain. International Journal of Radiation Oncology Biology Physics, 82(5): 1559-1566. PMID: 22429332.
- Lee WH, Cho HJ, Sonntag WE, Lee YW. Radiation attenuates physiological angiogenesis by differential expression of VEGF, Ang-1, Tie-2, and Ang-2 in rat brain. Radiation Research, 176(6): 753-760. PMID: 21962003.
- Conner K, Forbes ME, Lee WH, Lee YW, Riddle D. AT1 receptor antagonism does not influence early radiation-induced changes in microglial activation or neurogenesis in the normal rat brain. Radiation Research, 176(1):71-83. PMID: 21545290.
- Lee YW, Lee WH, Kim PH. Role of NADPH oxidase in interleukin-4-induced monocyte chemoattractant protein-1 expression in vascular endothelium. Inflammation Research, 59(9): 755-765. PMID: 20349326
- Lee YW, Kim PH, Lee WH, Hirani AA. Interleukin-4, oxidative stress, vascular inflammation and atherosclerosis. Biomolecules and Therapeutics, 18(2):135-144. PMID: 21072258.
- Lee WH, Sonntag WE, Lee YW. Aging attenuates radiation-induced expression of pro-inflammatory mediators in rat brain. Neuroscience Letter, 476(2):89-93. PMID: 20385203.
- Lee YW, Lee WH, Kim PH. Oxidative mechanisms of IL-4-induced IL-6 expression in vascular endothelium. Cytokine, 49(1):73-79. PMID: 19822443.
- Lee WH, Sonntag WE, Mitschelen M, Yan H, Lee YW. Irradiation induces pro-inflammatory environments in rat brain. International Journal of Radiation Biology, 86(2):132-144. PMID: 20148699.
- Lee WH, Kang S, Vlachos PP, Lee YW. A novel in vitro ischemia/reperfusion injury model. Archives of Pharmacal Research, 32(3):421-429. PMID: 19387587.
- Lee YW, Lee WH. Protective effects of genistein on pro-inflammatory pathways in human brain microvascular endothelial cells. Journal of Nutritional Biochemistry, 19(12):819-825. PMID: 18479900.
